癌症的放疗往往就是将患者或者肿瘤部位直接暴露于电离辐射下,比如伽玛射线或X射线等,放疗方法可以永久性地损伤癌细胞;但是不幸的是,放疗往往对健康组织也有具有伤害作用,尤其是对肿瘤部位外部的皮肤组织,所以这种癌症疗法往往使得患者面临脱发、皮肤病甚至皮肤癌的风险,因此开发使得患者能够免于放疗引发的副作用的新型策略一直是科学家们感兴趣的领域。 近日,刊登在国际杂志Int. J. Low Radiation上的一篇研究论文中,来自阿曼尼兹瓦大学等处的研究人员通过研究揭示了,三种普遍存在的植物天然衍生物保护患者免于放疗伽玛射线引发的皮肤损伤的分子机制。 文章中,研究者在非毒性浓度下检测了有机的抗氧化物咖啡酸(CA)、罗丹酚酸(RA)以及反式肉桂酸(TCA)对患者的有益作用,研究者检测了这些化合物抵御伽玛射线降低皮肤细胞产生活性氧的水平及保护性效应,结果显示,利用上述三种抗氧化物均可以有效保护患者的皮肤细胞免于伽玛射线的毒性伤害,保护的效率分别为40%(CA)、20%(RA)和15%(TCA)。 研究者表示,保护性效应的产生是因为这些抗氧化物可以“吞掉”活性氧并且化学性地对其灭活,与此同时还可以增强机体DNA的修复机制。 最后研究者建议,这些化合物或许可以被用于化疗或放疗期间患者的皮肤保护剂来使用,未来研究中研究人员将会通过进行更为深入的临床试验来检测上述三种抗氧化物的潜在性能。
doi:10.1504/IJLR.2014.063414
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An in vitro evidence for caffeic acid, rosmarinic acid and trans cinnamic acid as a skin protectant against γ-radiation Faruck Lukmanul Hakkim; Miwa Miura; Naoki Matsuda; Ahmed Suleiman Alharassi; Gilles Guillemin; Motohiro Yamauchi; Girija Arivazhagan; Hyuk Song
Ionising radiation (γ or X-rays) is the mandatory tool to treat cancer despite its detrimental effects in particular on skin cells which lead to severe dermatological diseases and carcinogenesis. Natural antioxidants caffeic acid (CA), rosmarinic acid (RA), trans cinnamic acid (TCA), p-coumaric acid (PCA), and hydroxyphenyllactic acid (HPA) acid are known to be potent anticancer and antioxidant agents. Current study is designed to provide experimental evidence as these compounds offer radiation protection for skin cells. Non-toxic concentrations of CA, RA, TCA, PCA, and HPA were tested for radiation protection, γ-radiation induced intracellular reactive oxygen species (ROS) by flow cytometry and DNA double strand break in human keratinocytes (HaCaT cells) by immunocytochemistry. CA, RA and TCA pre-treatment can protect the HaCaT cells by 40%, 20%, 15% respectively through scavenging γ-radiation induced ROS and decreasing number of post irradiation 53bp1 foci. Inclusion of these compounds in chemo-radiotherapy could facilitate to achieve multiple target protection (i.e. anti-cancer and skin radio protectant).
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